Updated: Apr 15, 2020
CB1 #receptors are displayed on nerve cells in the the brain, in the central nervous system (CNS), spinal cord, but they are also found in some peripheral organs and tissues. This wide distribution of the receptors may help to explain the diverse effects of managing the endocannabinoid signalling system and thereby modulating a wide range of neural functions, such as motor activity, learning, and memory.
The CB2 receptors are mainly found on white blood cells, in the tonsils and in the spleen.
In the immune system, one crucial function of the cannabinoid receptors is the regulation of cytokine release. CB2 receptor agonists have become increasingly popular subjects of research for their potential anti-inflammatory and anti-cancer effects.